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Job description
Topos Bio
At Topos Bio, we're pioneering drug discovery for intrinsically disordered proteins—targets that have eluded conventional approaches in neurodegeneration, oncology, and cardiometabolic disease.
We're seeking a cell biologist to develop and execute cell-based assays for validating computational predictions and supporting medicinal chemistry efforts. You'll work at the interface of disease biology, protein biophysics, and drug screening.
What you will do
Develop and optimize mammalian cell-based assays for disordered protein targets
Execute phenotypic and reporter-based screening campaigns to validate computational hits
Characterize compound activity and support structure-activity relationship studies
Collaborate with computational scientists to integrate experimental data with modeling workflows
Establish robust assay protocols and quality control metrics
What we are looking for
Strong foundation in mammalian cell culture and cellular assay development
Experience with disease-relevant cellular models
Ability to troubleshoot complex biological systems and optimize experimental protocols
Track record of productivity and effective collaboration
Preferred
PhD in cell and molecular biology with focus on disease models
Industry experience in drug discovery or biotech
Experience with reporter assays and high-throughput screening platforms
Familiarity with oncology, neurodegeneration, or metabolic disease models
Track record of developing novel cellular assays or screening approaches